Check whether your IP or domain is blacklisted in popular DNS-RBLs.
DNSBLs (Spamhaus, SpamCop, Barracuda and others) are databases of IPs and domains caught sending spam. Receiving mail servers query them on every incoming message: a listing in even one major blacklist can drop your deliverability to zero.
Check your SMTP server’s IP and your sending domain before launching a campaign and after any delivery complaints. If you are listed, fix the root cause first (compromised account, open relay, recipient complaints), then request delisting.